In Lorenzo il Magnifico: Houses of Renaissance, each player now becomes the head of a powerful house of Renaissance, each of which has a strong special ability that only that player can use. Players choose the houses from the ten available at the beginning of the game through a special and fast auction.

This expansion also introduces:
- 48 new Development Cards and a fifth tower, where these cards are placed. These cards add to the game a lot of new powerful effects.
- 20 new Leader Cards with a new leader mechanism.
- 30 special tokens that player can take and use in combination with the new cards, and that add new way to collect resources and perform actions.
- The components to add a fifth player to the struggle for the power.
Note: This copy includes the small promo expansion from Spiel'17 in Essen. It adds 2 new leaders (Carlo VIII & Jacopo Salviati) to play with the base game.
